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Results for "

P-glycoprotein inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	P-glycoprotein (77) 5-HT Receptor (5) ADC Cytotoxin (3) Adrenergic Receptor (1) AMPK (1) Antibiotic (2) Apoptosis (12) Autophagy (5) Bacterial (3) BCRP (5) Biochemical Assay Reagents (1) c-Met/HGFR (2) Calcium Channel (10) CFTR (3) Chloride Channel (2) Cholinesterase (ChE) (1) Cytochrome P450 (12) Dopamine Receptor (5) Drug Metabolite (4) Endogenous Metabolite (6) Glutathione S-transferase (1) HIV (5) HIV Protease (5) Isotope-Labeled Compounds (8) Microtubule/Tubulin (5) Mitochondrial Metabolism (4) Parasite (2) Potassium Channel (3) Ras (1) Reactive Oxygen Species (1) SARS-CoV (5) TAM Receptor (2)
By Research Areas:	Cancer (70) Cardiovascular Disease (8) Infection (9) Inflammation/Immunology (3) Metabolic Disease (10) Neurological Disease (6)

By Targets:

P-glycoprotein (77)

5-HT Receptor (5)

ADC Cytotoxin (3)

Adrenergic Receptor (1)

AMPK (1)

Antibiotic (2)

Apoptosis (12)

Autophagy (5)

Bacterial (3)

BCRP (5)

Biochemical Assay Reagents (1)

c-Met/HGFR (2)

Calcium Channel (10)

CFTR (3)

Chloride Channel (2)

Cholinesterase (ChE) (1)

Cytochrome P450 (12)

Dopamine Receptor (5)

Drug Metabolite (4)

Endogenous Metabolite (6)

Glutathione S-transferase (1)

HIV (5)

HIV Protease (5)

Isotope-Labeled Compounds (8)

Microtubule/Tubulin (5)

Mitochondrial Metabolism (4)

Parasite (2)

Potassium Channel (3)

Ras (1)

Reactive Oxygen Species (1)

SARS-CoV (5)

TAM Receptor (2)

By Research Areas:

Cancer (70)

Cardiovascular Disease (8)

Infection (9)

Inflammation/Immunology (3)

Metabolic Disease (10)

Neurological Disease (6)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Glycoprotein VI P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119823

PGP-4008	P-glycoprotein	Cancer
PGP-4008 is a specific *P-glycoprotein* (Pgp) inhibitor. PGP-4008 inhibits tumor growth in a murine syngeneic Pgp-mediated multiple agent resistance (MDR) solid tumor model when given in combination with Doxorubicin .

HY-19626

NSC23925

P-glycoprotein Cancer

NSC23925 is a novel, selective and effective P-glycoprotein (Pgp) inhibitor.
HY-13646

Encequidar

2 Publications Verification

HM30181; HM30181A
P-glycoprotein Metabolic Disease

Encequidar (HM30181; HM30181A) is a potent and selective inhibitor of P-glycoprotein.

NSC23925	P-glycoprotein	Cancer
NSC23925 is a novel, selective and effective *P-glycoprotein* (Pgp) inhibitor.

Encequidar 2 Publications Verification HM30181; HM30181A	P-glycoprotein	Metabolic Disease
Encequidar (HM30181; HM30181A) is a potent and selective inhibitor of *P-glycoprotein*.

HY-13646A

Encequidar mesylate 2 Publications Verification HM30181 mesylate; HM30181A mesylate	P-glycoprotein	Cancer
Encequidar mesylate (HM30181 mesylate; HM30181A mesylate) is a competitive and potent *P-glycoprotein* inhibitor.

HY-157330

P-gp inhibitor 16	P-glycoprotein Apoptosis	Cancer
P-gp inhibitor 16 (compound 14) is a *p-glycoprotein* inhibitor. P-gp inhibitor 16 significantly increases Doxorubicin-induced apoptosis and shows anticancer effects .

HY-107212

Selamectin	Parasite Chloride Channel P-glycoprotein Bacterial	Infection
Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, *Lymphatic filariae, and nematode* infection. Selamectin is also a potent *P-glycoprotein* substrate and a *P-glycoprotein* inhibitor with an IC₅₀ of 120 nM .

HY-17384

Valspodar 10+ Cited Publications PSC 833	P-glycoprotein	Cancer
Valspodar (PSC 833) is a selective *P-glycoprotein* inhibitor that has been used as an experimental cancer treatment and chemosensitizer.

HY-10550A

Tariquidar methanesulfonate, hydrate Maximum Cited Publications 46 Publications Verification XR9576 methanesulfonate, hydrate	P-glycoprotein	Cancer
Tariquidar methanesulfonate, hydrate (XR9576 methanesulfonate, hydrate) is a potent and specific inhibitor of *P-glycoprotein* (P-gp) with a K_d of 5.1 nM.

HY-125486

Reversin 121	P-glycoprotein	Cancer
Reversin 121 is a *P-glycoprotein* inhibitor. Reversin 121 increases the ATPase activity of MDR1. Reversin 121 reverses P-glycoprotein-mediated multidrug resistance. Reversin 121 can be used in the research of cancers .

HY-107212R

Selamectin (Standard)	Parasite Chloride Channel P-glycoprotein Bacterial	Infection
Selamectin (Standard) is the analytical standard of Selamectin. This product is intended for research and analytical applications. Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, *Lymphatic filariae, and nematode* infection. Selamectin is also a potent *P-glycoprotein* substrate and a *P-glycoprotein* inhibitor with an IC₅₀ of 120 nM .

HY-10550

Tariquidar Maximum Cited Publications 46 Publications Verification XR9576	P-glycoprotein	Cancer
Tariquidar (XR9576) is a potent and specific inhibitor of *P-glycoprotein* (P-gp) with the high affinity (K_d=5.1 nM) .

HY-110377

Tariquidar dihydrochloride XR9576 dihydrochloride	P-glycoprotein	Cancer
Tariquidar dihydrochloride (XR9576 dihydrochloride) is a potent and specific inhibitor of *P-glycoprotein* (P-gp) with the high affinity (K_d=5.1 nM) .

HY-15134

ONT-093

OC 144-093; OC 144093
P-glycoprotein Cancer

ONT-093 is a potent inhibitor of P-glycoprotein pump. ONT-093 has the potential for the research cancer diseases .
HY-W009141

1-Monopalmitin

Glyceryl palmitate
P-glycoprotein Cancer

1-Monopalmitin, a bitter melon extract, inhibits the P-glycoprotein (P-gp) activity in intestinal Caco-2 cells .

ONT-093 OC 144-093; OC 144093	P-glycoprotein	Cancer
ONT-093 is a potent inhibitor of P-glycoprotein pump. ONT-093 has the potential for the research cancer diseases .

1-Monopalmitin Glyceryl palmitate	P-glycoprotein	Cancer
1-Monopalmitin, a bitter melon extract, inhibits the P-glycoprotein (P-gp) activity in intestinal Caco-2 cells .

HY-100750

Norverapamil hydrochloride 1 Publications Verification (±)-Norverapamil hydrochloride; D591 hydrochloride	Calcium Channel P-glycoprotein Drug Metabolite	Cardiovascular Disease
Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor .

HY-135328

Norverapamil (±)-Norverapamil; D591	Calcium Channel P-glycoprotein Drug Metabolite	Cardiovascular Disease
Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor .

HY-107643

Reversan

CBLC4H10
P-glycoprotein Cancer

Reversan (CBLC4H10) is a potent and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (Pgp) inhibitor .
HY-136934

Reversin 205

[Boc-Glu(Obzl)]2-Lys-Ome
P-glycoprotein Cancer

Reversin 205 ([Boc-Glu(Obzl)]2-Lys-Ome) is a P-glycoprotein (ABCB1) inhibitor. Reversin 205 is a peptide chemosensitizer .

Reversan CBLC4H10	P-glycoprotein	Cancer
Reversan (CBLC4H10) is a potent and nontoxic *multidrug resistance-associated protein* 1 (MRP1)** and P-glycoprotein (Pgp) inhibitor .

Reversin 205 [Boc-Glu(Obzl)]2-Lys-Ome	P-glycoprotein	Cancer
Reversin 205 ([Boc-Glu(Obzl)]2-Lys-Ome) is a *P-glycoprotein* (ABCB1) inhibitor. Reversin 205 is a peptide chemosensitizer .

HY-N0425

Epoxylathyrol	P-glycoprotein	Cancer
Epoxylathyrol, an epoxylathyrane derivative isolated from the Euphorbia boetica, is a P-glycoprotein (P-gp) inhibitor. Epoxylathyrol is a P-gp-mediated multidrug resistance (MDR) reverser .

HY-A0279A

Pristinamycin IA 1 Publications Verification Mikamycin B; Mikamycin IA	Bacterial Antibiotic	Infection
Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of *P-glycoprotein* and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus .

HY-N0144

Piperine 5+ Cited Publications Bioperine; 1-Piperoylpiperidine	P-glycoprotein Autophagy Endogenous Metabolite	Inflammation/Immunology Cancer
Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits *P-glycoprotein* and CYP3A4 activities with an IC₅₀ value of 61.94±0.054 μg/mL in HeLa cell.

HY-126906

Milbemycin A4	Antibiotic P-glycoprotein	Cancer
Milbemycin A4 inhibits *P-glycoprotein* activity, and reverses multidrug resistance of tumor cells. Milbemycins are a family of macrolide antibiotics with insecticidal and acaricidal activity sup>[2].

HY-N6932

Voacamine
Voacamine, an indole alkaloid, exhibits potent cannabinoid CB1 receptor antagonistic activity . Voacamine also inhibits *P-glycoprotein* (P-gp) action in multidrug-resistant tumor cells .

HY-133948

1-Monopalmitolein Glyceryl palmitoleate	Biochemical Assay Reagents	Others
1-Palmitoleoyl glycerol is a biologically active monoacylglycerol. It increases daunomycin accumulation, shown to inhibit P-glycoprotein in Caco-2 cells. 1-Palmitoleoyl glycerol induces thymocyte apoptosis.

HY-135328AS

Norverapamil-d7 hydrochloride (±)-Norverapamil-d₇ (hydrochloride); D591-d7 (hydrochloride)	Calcium Channel	Cardiovascular Disease
Norverapamil-d₇ (hydrochloride) is a deuterium labeled Norverapamil. Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

HY-135328S

Norverapamil-d7 (±)-Norverapamil-d₇; D591-d₇	Calcium Channel P-glycoprotein Drug Metabolite	Cardiovascular Disease
Norverapamil-d₇ is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

HY-50671

Zosuquidar trihydrochloride 10+ Cited Publications RS 33295-198 trihydrochloride; LY-335979 trihydrochloride	P-glycoprotein	Cancer
Zosuquidar (LY335979) trihydrochloride is a *P-glycoprotein* (P-gp) inhibitor (K_i=59 nM). Zosuquidar trihydrochloride shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research .

HY-15255

Zosuquidar 10+ Cited Publications RS 33295-198; LY-335979	P-glycoprotein	Cancer
Zosuquidar (LY335979) is a *P-glycoprotein* (P-gp) inhibitor (K_i=59 nM). Zosuquidar shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research .

HY-50879

Elacridar 20+ Cited Publications GF120918; GW0918; GG918; GW120918	P-glycoprotein BCRP	Cancer
Elacridar is an orally active P-glycoprotein (Pgp) and *breast cancer resistance protein* (BCRP)** inhibitor. Elacridar can be used to examine the influence of efflux transporters on agent distribution to brain and the research of cancer .

HY-N1916

Coniferyl ferulate	Glutathione S-transferase P-glycoprotein	Cancer
Coniferyl ferulate, a strong inhibitor of glutathione S-transferase (GST), reverses multidrug resistance and downregulates P-glycoprotein. Coniferyl ferulate shows strong inhibition of human placental GST with an IC50 of 0.3 μM.

HY-135336

(R)-Verapamil hydrochloride (R)-(+)-Verapamil hydrochloride	P-glycoprotein Apoptosis	Cancer
(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a *P-Glycoprotein* inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents .

HY-13646C

Encequidar mesylate hydrochloride HM30181 mesylate hydrochloride; HM30181A mesylate hydrochloride	P-glycoprotein	Cancer
Encequidar (HM30181) mesylate hydrochloride is a potent and selective inhibitor of *P-glycoprotein* (MDR1). Encequidar mesylate hydrochloride improves anti-tumor efficacy of Paclitaxel (HY-B0015) in mouse tumor models .

HY-162396

P-gp inhibitor 21	P-glycoprotein	Cancer
P-gp inhibitor 21 (Compound 56) is an inhibitor for P-glycoprotein (P-gp) transport, which reverses P-gp-mediated multidrug resistance (MDR) and exhibits antitumor efficacy in mice without significant cytotoxicity .

HY-16191

ELR510444 1 Publications Verification	Microtubule/Tubulin Apoptosis	Cancer
ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpressing cell lines.

HY-N6684

Deoxynivalenol 4 Publications Verification Vomitoxin	Others	Metabolic Disease
Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

HY-N10491

Spongionellol A	P-glycoprotein	Cancer
Spongionellol A is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A can be used in the research of cancers, such as prostate cancer .

HY-N3085

Phellamurin	P-glycoprotein Apoptosis	Metabolic Disease Cancer
Phellamurin is a plant flavonone glycoside from the leaves of Phellodendron amurense and inhibits intestinal *P-glycoprotein. Phellamurin also inhibits* egg laying by Papilio protenor. Phellamurin induces cells apoptosis and has anti-tumor activity .

HY-N4108

Hypophyllanthin	P-glycoprotein	Inflammation/Immunology Cancer
Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity .

HY-19642A

Glesatinib hydrochloride 2 Publications Verification MGCD265 hydrochloride	TAM Receptor c-Met/HGFR	Cancer
Glesatinib hydrochloride (MGCD265 hydrochloride) is an orally active, potent MET/SMO dual inhibitor. Glesatinib hydrochloride, a tyrosine kinase inhibitor, antagonizes P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC) .

HY-19642

Glesatinib MGCD265	TAM Receptor c-Met/HGFR	Cancer
Glesatinib (MGCD265) is an orally active, potent MET/SMO dual inhibitor. Glesatinib, a tyrosine kinase inhibitor, antagonizes P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC) .

HY-113805

MC70	P-glycoprotein	Cancer
MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC₅₀ of 0.69 µM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1 .

HY-146391

P-gp inhibitor 4	P-glycoprotein	Cancer
P-gp inhibitor 4 (Compound 8b) is a selective *P-glycoprotein* modulator with an EC₅₀ of 94 nM. P-gp inhibitor 4 increases agent transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells .

HY-50880

Elacridar hydrochloride 20+ Cited Publications GF120918A	P-glycoprotein BCRP	Cancer
Elacridar hydrochloride (GF120918A) is an orally active P-glycoprotein (P-gp) and *breast cancer resistance protein* (BCRP)** inhibitor. Elacridar hydrochloride can be used to examine the influence of efflux transporters on agent distribution to brain and it can be used for the research of cancer .

HY-A0064

Verapamil hydrochloride 40+ Cited Publications (±)-Verapamil hydrochloride; CP-16533-1 hydrochloride	Calcium Channel P-glycoprotein Cytochrome P450	Cardiovascular Disease
Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research .

HY-14275

Verapamil 40+ Cited Publications (±)-Verapamil; CP-16533-1	Calcium Channel P-glycoprotein Cytochrome P450	Metabolic Disease Cancer
Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research .

HY-162369

PID-9	P-glycoprotein	Cancer
PID-9 is a *P-glycoprotein* inhibitor. PID-9 has multidrug resistance (MDR) reversal activity (IC₅₀ = 0.1338 μM) and low toxicity. PID-9 inhibits the transport function of P-gp without downregulating P-gp expression .

HY-N2947

Boeravinone B	P-glycoprotein	Infection Inflammation/Immunology
Boeravinone B, a dual inhibitor of NorA bacterial efflux pump of Staphylococcus aureus and human P-Glycoprotein, reduces the biofilm formation and intracellular invasion of bacteria. Boeravinone B act as anti-aging and anti-apoptosis phyto-molecules during oxidative stress .

HY-11018

Risperidone 4 Publications Verification R 64 766	5-HT Receptor Dopamine Receptor P-glycoprotein	Neurological Disease
Risperidone is a serotonin 5-HT₂ receptor blocker, *P-Glycoprotein* inhibitor and potent dopamine D₂ receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively.

HY-144366

P-gp inhibitor 3	P-glycoprotein	Cancer
P-gp inhibitor 3 is an effective *P-glycoprotein* (P-gp) inhibitor. P-gp inhibitor 3 inhibits the efflux function of P-gp by activating P-gp ATPase. P-gp inhibitor 3 has relatively stronger multidrug resistance (MDR) reversal ability and enhances the anti-tumor activity of Paclitaxel .

HY-146096

RMS3	P-glycoprotein Apoptosis	Cancer
RMS3, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS3 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS3 causes PARP cleavage, a marker for cells undergoing apoptosis. RMS3 has strong anticancer property .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W009141

1-Monopalmitin Glyceryl palmitate	Source classification Plants	P-glycoprotein
1-Monopalmitin, a bitter melon extract, inhibits the P-glycoprotein (P-gp) activity in intestinal Caco-2 cells .

HY-A0279A

Pristinamycin IA 1 Publications Verification Mikamycin B; Mikamycin IA	Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Cyclopeptides Source classification Other Diseases Antibacterial Disease Research Disease Research Fields	Bacterial Antibiotic
Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of *P-glycoprotein* and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus .

HY-N0144

Piperine 5+ Cited Publications Bioperine; 1-Piperoylpiperidine	Structural Classification Classification of Application Fields Source classification Piperaceae Plants Endogenous metabolite Biological Pesticide Research Piper nigrum Linn. Agricultural Research Alkaloids Piperidine Alkaloids Disease Research Fields Cancer	P-glycoprotein Autophagy Endogenous Metabolite
Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits *P-glycoprotein* and CYP3A4 activities with an IC₅₀ value of 61.94±0.054 μg/mL in HeLa cell.

HY-N1916

Coniferyl ferulate	Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Dicerothamnus rhinocerotis Phenylpropanoids Umbelliferae Plants Disease Research Fields Cancer	Glutathione S-transferase P-glycoprotein
Coniferyl ferulate, a strong inhibitor of glutathione S-transferase (GST), reverses multidrug resistance and downregulates P-glycoprotein. Coniferyl ferulate shows strong inhibition of human placental GST with an IC50 of 0.3 μM.

HY-N0425

Epoxylathyrol	Structural Classification Classification of Application Fields Euphorbia boetica Terpenoids Source classification Diterpenoids Euphorbiaceae Plants Disease Research Fields Cancer	P-glycoprotein
Epoxylathyrol, an epoxylathyrane derivative isolated from the Euphorbia boetica, is a P-glycoprotein (P-gp) inhibitor. Epoxylathyrol is a P-gp-mediated multidrug resistance (MDR) reverser .

HY-N6684

Deoxynivalenol 4 Publications Verification Vomitoxin	Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Metabolic Disease Disease Research Fields	Others
Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

HY-N10491

Spongionellol A	Microorganisms Source classification Diterpenoids	P-glycoprotein
Spongionellol A is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A can be used in the research of cancers, such as prostate cancer .

HY-N3085

Phellamurin	Flavanonols Phellodendron amurense Rupr. Flavonoids Classification of Application Fields Source classification Rutaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	P-glycoprotein Apoptosis
Phellamurin is a plant flavonone glycoside from the leaves of Phellodendron amurense and inhibits intestinal *P-glycoprotein. Phellamurin also inhibits* egg laying by Papilio protenor. Phellamurin induces cells apoptosis and has anti-tumor activity .

HY-N4108

Hypophyllanthin	Phyllanthus urinaria Linn. Structural Classification Classification of Application Fields Source classification Lignans Euphorbiaceae Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	P-glycoprotein
Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity .

HY-N2947

Boeravinone B	Natural Products other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	P-glycoprotein
Boeravinone B, a dual inhibitor of NorA bacterial efflux pump of Staphylococcus aureus and human P-Glycoprotein, reduces the biofilm formation and intracellular invasion of bacteria. Boeravinone B act as anti-aging and anti-apoptosis phyto-molecules during oxidative stress .

HY-N0692

Schisandrol B 1 Publications Verification Gomisin-A; TJN-101; Wuweizi alcohol-B	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer	Reactive Oxygen Species Cytochrome P450 Autophagy
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of *P-glycoprotein* and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .

HY-N10492

Spongionellol A analog 1	Microorganisms Source classification Diterpenoids	P-glycoprotein
Spongionellol A analog 1, an analog of Spongionellol A (HY-10491), is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A analog 1 has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A analog 1 can be used in the research of cancers, such as prostate cancer .

HY-N3028

Taccalonolide B	Structural Classification Classification of Application Fields Source classification Schizocapsa plantaginea Hance Plants Disease Research Fields Taccaceae Steroids Cancer	Microtubule/Tubulin
Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC₅₀ of 208 nM .

HY-N0069

Solamargine Maximum Cited Publications 11 Publications Verification Solamargin; δ-Solanigrine	Structural Classification Alkaloids Piperidine Alkaloids Solanum Classification of Application Fields Plants Solanaceae Disease Research Fields Saccharides Steroids Cancer	P-glycoprotein Apoptosis
Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and *P-glycoprotein* inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity .

HY-17367

Atazanavir Maximum Cited Publications 11 Publications Verification BMS-232632	Infection Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 3.49 μM .

HY-17367A

Atazanavir sulfate Maximum Cited Publications 11 Publications Verification BMS-232632 sulfate	Infection Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (BMS-232632) sulfate, a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir sulfate is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 3.49 μM .

HY-N10564

8α,9α-Epoxycoleon-U-quinone	Structural Classification Ketones, Aldehydes, Acids Labiatae Smallanthus uvedalia (Linnaeus) Mackenzie Plants	P-glycoprotein
8α,9α-Epoxycoleon-U-quinone (compound 3) is a p-glycoprotein (P-gp) regulator that is selective for cancer cells (SI=2.0). 8α,9α-Epoxycoleon-U-quinone effectively inhibits P-gp activity in NCI-H460/R cells. 8α,9α-Epoxycoleon-U-quinone also reverses the resistance of cancer cells to Doxorubicin (DOX) (HY-15142A) and enhances the anticancer effect of DOX .

HY-N10075

Euphohelioscopin A	Structural Classification Terpenoids Source classification Euphorbia helioscopia L. Diterpenoids Euphorbiaceae Plants	P-glycoprotein
Euphohelioscopin A is a diterpenoid can be isolated from the Euphorbia helioscopia L. plant. Euphohelioscopin A weakly inhibits P-glycoprotein-mediated efflux of mitoxantrone .

Cat. No.	Product Name	Chemical Structure

HY-135328AS

Norverapamil-d7 hydrochloride
Norverapamil-d₇ (hydrochloride) is a deuterium labeled Norverapamil. Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

HY-A0064S

Verapamil-d3 hydrochloride

Verapamil-d₃ (hydrochloride) is the deuterium labeled Verapamil hydrochloride. Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research[1][2][3].

HY-110232

Risperidone-d4
Risperidone-d₄ is the deuterium labeled Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.

HY-135328S

Norverapamil-d7
Norverapamil-d₇ is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

HY-135336S

(R)-Verapamil-d7 hydrochloride
(R)-Verapamil-d₇ (hydrochloride) is a deuterium labeled (R)-Verapamil hydrochloride. (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents[1][2].

HY-14275S1

Verapamil-d7
Verapamil-d₇ is the deuterium labeled Verapamil (HY-14275). Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research .

HY-17367S3

Atazanavir-d5

Atazanavir-d₅ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-17367S2

Atazanavir-d9

Atazanavir-d₉ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-17367S4

Atazanavir-d6

Atazanavir-d₆ is deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-A0064S1

Verapamil-d6 hydrochloride

Verapamil-d₆ (CP-16533-1-d₆) hydrochloride is the deuterium labled Verapamil (hydrochloride) (HY-A0064). Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research .

HY-11018S2

Risperidone-d6
Risperidone-d6 (R 64 766-d6) is the deuterium labeled Risperidone (HY-11018). Risperidone is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent dopamine D₂ receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively .

HY-15206S

Glyburide-d11

Glyburide-d₁₁ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-15206S1

Glyburide-d3

Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

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